![]() 140 Proof is headquartered in San Francisco, California, and backed by a $2 million investment from Blue Run Ventures and Founders Fund raised in the summer of 2009. 140 Proof's patent-pending algorithm reaches the right audience across mobile devices, desktop clients, and the web: wherever tweets are served. ![]() 140 Proof matches ads to people by what they care about, using public Twitter data. Echofon is created by naan studio, a software company based in Mountain View, California whose social networking apps have been downloaded more than 6.5 million times.ġ40 Proof is the first scalable ad solution built exclusively for Twitter. For additional information on Echofon, visit Įchofon is a suite of Twitter apps available for iPhone, Mac and as a Firefox extension. "We are excited to be working with Echofon, the best Mac app for Twitter."įor more information on 140 Proof, please visit. Also it has a small text input field to update your tweets. This extension adds a tiny icon on the status bar that notifies you when your friends update their tweets. You can also attach screen captures, current iTunes song, or current page in Safari. Dont worry, Echofon allows you to have more than one account and be logged on them at the same time to know what happens in your different Twitter worlds. Easily attach photos to your tweets with drag-and-drop. It stays out of the way when necessary and expands to support all the advanced features you need, when you need them. Very minimalistic, if that's what you like (I do like its. third option, Twitters TweetDeck, is not a native Mac app, but more. The Echofon interface was carefully designed to be comfortably left open all day. Echofon: 20 from with syncing to the same company's iPhone app. 140 Proof is thrilled to be partnering with great application developers like Echofon and monetizing the vast Twitter ecosystem today." said CEO Jon Elvekrog. Displayed below are Twitterrific and Tweetbot, along with the now-defunct Twitter for Mac. "We're excited that Twitter has followed a similar strategy for monetizing the 25% of users who use. "We pride ourselves on a clean Twitter experience, and integrating 140 Proof ads allows us to monetize without impacting the great user experience we've worked hard to create," said Kazuho Okui of naan studio, creator of Echofon. Users can interact with ads, just as they do with normal tweets: they can be replied to, retweeted, or favorited. ![]() Users can also attach screen captures, the song they are listening to, or the web page they are currently viewing to a tweet.ġ40 Proof's personalized ad solution allows advertisers to reach Echofon's loyal user base, with relevant, unobtrusive ads that resonate with users. The app has a simple, clean user interface which allows users to easily attach photos to your tweets with drag and drop. Which obviously I’d rather not do,” Haddad said.Īfter a user asked Haddad what was stopping Tweetbot from obtaining a new API key, he said (Opens in a new window) he could remotely update new keys in “5-10 minutes” but did not want to “get sued by someone with an unlimited legal budget.SAN FRANCISCO, April 13 /PRNewswire/ - Echofon released version 1.0 of their Twitter app for the Mac today, which can be purchased for $20 or is available for free with ads by 140 Proof. If we’re permanently cut off I need to know so we can remove the app from sale and prevent those. Renewals for year 3 of Tweetbot coming up in a couple of weeks. Tweetbot co-founder Paul Haddad wrote on Mastodon (Opens in a new window) on Saturday that he is waiting for an official public statement from Twitter in regards to the cut-off, and is completely in the dark as to whether the shutdown is permanent or not. Third-party apps rely on Twitter’s API to function, which Twitter has the power to shut down. Tweetdeck is reportedly (Opens in a new window) unaffected by the shutdowns. The outages, which have also affected Twitteriffic, Fenix, and Talon on both Android, iOS and MacOS, are widely reported to have occurred because the apps generally do not bring in any ad revenue for the social media company, and they allow users to bypass ad-rich features such as the “For You” page. As of Sunday morning, Twitter has still not addressed the problem on either its official page (Opens in a new window) or the Twitter Support account (Opens in a new window), while CEO Elon Musk (Opens in a new window) has remained silent too. Many third-party Twitter clients such as Tweetbot and Echofon are still down after they stopped working Thursday night, a situation that is reportedly intentional (Opens in a new window).Īccording to internal messages viewed by The Information, the outages were “intentionally” performed by Twitter to force third-party users to use Twitter’s own app. How to Set Up Two-Factor Authentication.How to Record the Screen on Your Windows PC or Mac.How to Convert YouTube Videos to MP3 Files.How to Save Money on Your Cell Phone Bill.How to Free Up Space on Your iPhone or iPad.How to Block Robotexts and Spam Messages.
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![]() When that start happening then it is predictable that the volume will cut off and only it it resets by cycling power. Some time the coil split just have no effect or the piezo volume becomes the entire system volume. the Magnetic pickups become inverted in the way that neck becomes bridge position and bridge position becomes the neck. When the problem hapens the guitar starts behaving oddly. I am certain that it has to do with the guitar preamp. Is a shame that I am finding my self on this predicament because all this gear is extremely expensive. This does not happen with my passive guitars. The common denominator are my MusicMan Monarch Majesty Guitars (2X6 string and 1X7 string). My Kemper cuts out to about 30% and then it just cuts to 0% while playing. Which software revision is installed? We are at 5.4.1 Release. Is the issue related to particular Modes or Rigs or Slots? - No, the same behaviour in all the modes cables, speakers.? - I tried different guitar cables with the same result ![]() Have you checked the connected monitoring equipment. the Speaker Output? - All outputs affected, main outputs, headphones. What is the level of the relevant output volume - not Master Volume - but for example Monitor Output Volume in dB? - No idea but the problem is in the input signal not in the outputĭoes the issue affect all outputs or just one e. ![]() Output LED - is this still reflecting a signal?.- The output led shows no signal as there is no input affected Control Change #7? - No MIDI involved in the problem I tried different patches with the same result. Volume Pedal - where is the level of the Volume Pedal controller in the System Settings? If that isn't at maximum, what is causing it? Which socket(s) is/are assigned to the function Volume Pedal? What is connected to those sockets? What if you disconnect pedals or disable unused sockets? - No volume pedal connected to the kemper. I tried two input sources ( input and alternative input) with teh same result. The Kemper was not connected to any audio interface just connected to the power amp. So, the activation of your audio interface could cause the Front Input to mute. Input Source - while your Input Source is for example set to "SPDIF Input Reamp" the Front Input is still functional, but only until an SPDIF cable gets connected AND a synchronization signal is received at the Profiler's SPDIF In. Input LED - is the input LED still functional or dead or frozen? - The input LED shows no signal Which software revision is installed? We are at 5.4.1 Release.īurkhard, I thougth the list of questions was directed to MetalMauce. Is the issue related to particular Modes or Rigs or Slots? What is the level of the relevant output volume - not Master Volume - but for example Monitor Output Volume in dB?ĭoes the issue affect all outputs or just one e. ![]() Output LED - is this still reflecting a signal?. Volume Pedal - where is the level of the Volume Pedal controller in the System Settings? If that isn't at maximum, what is causing it? Which socket(s) is/are assigned to the function Volume Pedal? What is connected to those sockets? What if you disconnect pedals or disable unused sockets? Input LED - is the input LED still functional or dead or frozen? Complete loss of input signal is not the same as drop of output signal!? If you don't hear anything but the Tuner is still functional it's probably not an issue with the input signal. So far I see no evidence, that these are the "same issues". The Void usually takes the form of a shadowy monsters that possesses vast shapeshifting and mental powers. The psychic powers are also tied to the Void, as the persona is a projection of Reynolds’ self-loathing and guilt. In the past, he’s been able to erase the memories of everyone on Earth so they would forget about him. Sentry’s psionic abilities are powerful as well. He also gave his powers to a dog named Normie, who became Watchdog. Reynolds infused the boy with his powers so Turner could become his sidekick, Scout. Reynolds can also share his powers with others, as seen with a boy named Billy Turner. Sentry has displayed the power of photokinesis, emitting a bright light that has been shown to calm Hulk down. When his wife was murdered by Ultron, Reynolds brought her back to life simply by touching her. In addition, Sentry has shown to possess the power of resurrection and other passive abilities. As the Void, Reynolds has broken the Hulk’s bones with ease. He’s been shown to be strong enough to kill Ares by ripping him in half, overload the absorbing abilities of The Absorbing Man and break the cosmic axe of Terrax the Tamer. Sentry’s superhuman strength makes him one of the most powerful characters in the Marvel Universe. Reynolds doesn’t have full control of this ability, but he could potentially achieve any feat. ![]() As both personalities are essentially the same person, Reynolds has been able to shapeshift and alter the world around him. It’s possible that Sentry and Void’s other powers stem from molecular manipulation. This ability has allowed Sentry to resurrect himself from complete destruction. Reynolds discovered this ability when fighting Molecule Man. During the Dark Avengers story arc, Sentry was revealed to have the power of molecular manipulation and reality warping. Over time, Sentry’s powers were expanded on. When Sentry was first introduced, he had all the standard powers of a Superman character: superhuman strength, flight, speed, senses etc. ![]() The serum shifted his molecules to the point that Sentry is out of sync with reality, which is likely why his darker half, the Void exists. ![]() But the potency was supercharged, giving Reynolds god-like strength. Robert Reynolds’ powers are derived from a version of the Super Soldier Serum that created Captain America. Considered to be omniscient, Sentry has the power of ‘a million exploding suns.’ But what does that mean? What is Sentry truly capable of? The Comic Vault is taking a closer look into his abilities. The Sentry has suffered from this problem because a lot of writers have added their own take. Sometimes, they aren’t clearly defined and that can lead to confusion or readers not being able to take the character seriously. When learning about a superhero, their powers are one of their most interesting aspects. ![]() "What I Get Paid For" does not appear on North American pressings of the album, therefore reducing the number of tracks to 12.Colvin then began her speech, remarking, "I'm confused now!" Track listing As Colvin was about to begin her speech after winning Song of the Year, rapper Ol' Dirty Bastard stormed the stage protesting his loss of an award that same night, saying, ".I don't know how you all see it, but when it comes to the children, Wu-Tang is for the children." leading him to be escorted off stage. She won both awards (sharing Song of the Year with Leventhal). At the next year's Grammy Awards, Colvin was nominated for Song of the Year and Record of the Year for "Sunny Came Home". In the 1997 Grammy Awards, she was nominated for Best Female Pop Vocal Performance award for "Get Out of This House" and Best Pop Album for A Few Small Repairs. Grammy success came to Colvin two years after the release of A Few Small Repairs. ( January 2023)Ī Few Small Repairs peaked at number 39 on the Billboard 200 chart. Colvin appeared on the show in the second season episode Ready. The song was also used on Suddenly Susan as its theme song from 1997 to 2000. The album's biggest single, released in 1997, was " Sunny Came Home", which peaked on the Billboard Hot 100 at number 7, and topped the Adult Contemporary, Adult Top 40, and Top 40 Adult Recurrents charts the same year.Īnother notable song from the album was "Nothin' on Me", which peaked at number 24 on Billboard 's Adult Top 40 chart. Singles Ī Few Small Repairs was supported by four singles. Colvin found the painting so arresting that she knew she wanted to use it as the cover before the songwriting and recording were done. The album cover consists of a painting by Colvin's friend Julie Speed of a three-eyed woman with a lit match, which inspired Colvin to write the song "Sunny Came Home". At the time of the album's release, she had relocated to Austin, Texas. Background Ī Few Small Repairs is a concept album about divorce, as Colvin's marriage was ending. ![]() It was released on Octoby Columbia Records. A Few Small Repairs is the fourth studio album by American singer-songwriter Shawn Colvin. All estimates and further details about each model specification are reported in Table A3 in S1 Online appendix. Standard errors are estimated allowing for clustering at the state-year level. Horizontal bars around point estimates illustrate 95% confidence intervals. The following controls are added sequentially in the other models: electoral record and political controls (Model 2), economic controls x majority party membership (Model 3), state fixed effects (Model 4), and state fixed effects x majority party membership (Model 5). Each row corresponds to a different model specification: Model 1 includes only time dummies and dummies for majority party membership and membership of the governor’s party as controls. Panel (a) shows results for outcome 1 (re-election), while Panels (b) and (c) show results for outcomes 2 (replaced by same-party candidate) and 3 (replaced by other-party candidate), respectively. The figure shows average marginal effects of changing the budget gridlock variable from zero to one on the probability of each of three possible election outcomes for incumbent legislators, allowing different effects for members of the governor’s party vs. All estimates and further details about each model specification are reported in Table A2 in S1 Online appendix.Įffects of budget gridlock: members of governor’s party vs. ![]() The figure shows average marginal effects of changing the budget gridlock variable from zero to one on the probability of each of three possible election outcomes for incumbent legislators, allowing different effects for majority vs. ![]() This could be attributed to their ease of access since you can play any game of your choice from any corner of the world, offers two zero spaces as well as much worse odds. Shopkick is currently partnered with more than 250,000 retail locations, and in a perfect world.
![]() Official Infoįrom The Black Temple in Under Development: The formal entrance to the Black Temple, littered with bones. For a full analysis of this issue, please see Black Citadel and Temple. It has been confirmed that the Black Citadel was renamed to Black Temple, although it is unclear why it was moved from the Hellfire Peninsula to Shadowmoon Valley. But then again, those afflicted by madness rarely make sense. While Malfurion has stated that Illidan has become mad and delusional, believing that he killed Arthas and accomplished the mission Kil'jaeden had sent him on, it said on the Burning Crusade website that "Illidan lives in fear that he will be discovered by his powerful enemies - most notably Arthas, the new Lich King, and the remaining Lords of the Burning Legion." If Illidan has descended into madness and believes he accomplished his mission it would make no sense for him to worry about Arthas or Kil'jaeden coming after him he would believe the former dead, and the latter appeased. Neither his activities nor mental state are known at this time. Renamed the Black Citadel, it was used as a "prime staging ground for the Burning Legion's campaign of destruction." Īfter Illidan conquered much of Outland, including the Black Temple, and following his defeat at the hands of Arthas Menethil, Illidan returned to the Black Temple where he resides to this day. Sometime after the destruction of Draenor it was taken over by the Burning Legion. In the trailer for the Black Temple, it shows the scene where Gul'dan's troops attack the temple. It was later used as a fortress for the then-mortal Ner'zhul. Shortly after the formation of the Horde, Gul'dan ordered the temple conquered and transformed it into the headquarters for the Shadow Council, renaming it the Black Temple in the process. īefore the shattering of Draenor, the Black Temple was once called the Temple of Karabor, a sacred site to the draenei which served as the refuge of the Prophet Velen. You must slay the demonic Illidari forces outside the Temple in order to provide a distraction for Akama and Maiev to slip into the Temple undetected. After this you are sent to Xi'ri outside the gates of Black Temple. ![]() The next part of the attunement involves killing Rage Winterchill, a lich boss, which is also the first boss in the Battle of Mount Hyjal instance. You will then need to slay Al'ar in the Eye of Tempest Keep so that Akama can convince Illidan he is still loyal. After delivering a message to Akama, he informs Illidan of Kael'thas' treachery in order to attempt to prove his loyalty (Illidan believes him, but is still suspicious). Then players adventuring in the Serpentshrine Cavern will have access to a quest from a Broken NPC named Seer Olum in Fathom-Lord Karathress's room (the quest is entitled The Secret Compromised). Below is a short guide on how to.įirst you have to complete Akama's Promise. Though the attunement is no longer required to gain entrance to the Temple, you can still complete it. 4 Akama and Maiev: Involvement in the TempleĪttunement Main article: Black Temple Attunement. ![]() Intending to move on with their lives, the twins return to Delos Crossing to sell their childhood home, but finds the house in a state of disrepair despite the efforts of Mary-Ann's friend Sam, who had turned to alcoholism since her death. Ten years later, an adult Tyler leaves the juvenile detention center he was sentenced to and reunites with Alyson, who has been adopted by Eddy, the investigating officer of the incident. The game opens with a flashback sequence showing Tyler's confession to the murder of his mother, Mary-Ann, in self-defense as a child in 2005. The twins' bond with each other may be tested, depending on whether their attitude and behavior validates the other twin's convictions or memories. The player's decisions during their interactions with the aforementioned non-player characters will define the circumstances of these characters as well as their relationships with the twins. It also includes Filipino Catholic Tessa Vecchi, who runs a convenience store alongside her husband. The game includes the culture of the Tlingit people, an indigenous community in the Pacific Northwest Coast of North America with several Tlingit characters such as Delos police chief Eddy Brown and Michael Abila, a colleague of Alyson as well as Tyler's potential love interest. Tyler's identity as a trans man is occasionally discussed or referenced within the game's narrative. A majority of the game's puzzles are derived from decoding the metaphors compiled in the storybooks, which delve into the fairy tale life Mary-Ann imagined for herself and her struggles to manage her own reality. Players can sometimes alternate between the perspectives of both siblings, whether in their interactions with the residents of Delos Crossing, or when going through the storybooks they played with as children. ![]() The player will make decisions for the pair based on which version of the past events they want their avatar character to believe, which will impact the outcome of the game's narrative. The central gameplay mechanic of the game involves players guiding the twins as they experience recollections and visions of what had transpired in a series of scenarios spread across three episodes, and piece together the plot by watching them unfold, with each individual having different interpretations of what happened. The twins share a supernatural bond that allow them to telepathically communicate with each other, and experience visions of past events which often manifests in vivid detail. state of Alaska and interact with its local residents. Besides their old home, which is maintained by Mary-Ann's friend Sam, the twins will also revisit parts of their fictional hometown of Delos Crossing in the U.S. Players control a pair of 21-year-old American twins, Tyler Ronan (voiced by August Aiden Black) and Alyson Ronan (voiced by Erica Lindbeck), as they revisit their childhood home following a traumatic event which resulted in the death of their mother Mary-Ann Ronan and a decade-long separation from each other. Criticisms included inconsistent storytelling and lack of engaging gameplay. It received generally favorable reviews, with critics praising the complex characters, voice acting, narrative design and setting, as well as its competent handling of culturally sensitive subjects such as transgender topics. A trans man was cast as the voice actor for Tyler Ronan, of the two main characters, who had transitioned during his time away from his sister. The developers consulted with expert groups for its themes, notably GLAAD, a non-governmental organization (NGO) monitoring media coverage of LGBT people, to ensure authentic and respectful portrayal of LGBT characters. Since it was announced in November 2019, the game has been noted for being the first AAA video game to feature a transgender person as a main character. A recurring theme of the story is the fallacy of memory, as the narrative explores the twins' childhood trauma and how they may each remember pivotal moments differently. It follows a pair of twins, Tyler and Alyson, with the ability to communicate with each other through telepathy, who reunite after ten years in their hometown in rural Alaska and investigate the death of their mother. The game consists of three chapters released for Windows and Xbox One in late 2020. ![]() Tell Me Why is an episodic adventure game developed by Dontnod Entertainment and published by Xbox Game Studios. ![]() Indeed, in the last 30 years a limited progress has been made in GBM treatment with current first-line standards-of-care involving maximal safe tumor resection with adjuvant temozolomide (TMZ)-based chemotherapy and radiotherapy. Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in adult humans, characterized by a poor prognosis despite the existence of multimodal therapy. Primarily, “Reprogramming Therapy”, which is aimed at reverting the malignant phenotype, is now considered a promising strategy for GBM therapy. Therefore, the emerging roles of BET protein in glioblastoma onco-biology and the compelling demand for more effective therapeutic strategies suggest that BET family members could be promising targets for translational breakthroughs in glioblastoma treatment. Interestingly, epigenome dysregulation associated with loss of cellular identity and functions are emerging as crucial features of glioblastoma pathogenesis. Recently, new insights are emerging about the glioblastoma cellular origin, leading to the hypothesis that several putative mechanisms occur during gliomagenesis. Glioblastoma is the most aggressive form of glioma, characterized by a very poor prognosis despite the application of a multimodal therapy. Transcriptome handling ability of BET proteins suggests a key role in the modulation of cell plasticity, both in fate decision and in lineage commitment during embryonic development and in pathogenic conditions, including cancerogenesis. The survival and reproductive success of an individual is directly related to how their traits help them to function and survive in their environment.BET proteins are a family of multifunctional epigenetic readers, mainly involved in transcriptional regulation through chromatin modelling. Mutations are random, but natural selection is not random. Is evolution a random process? Evolution is not a random process.Evolution repeats itself in different environments. Different mutations can cause the same phenotype (trait). Did the mice on each of the dark lava flows have the same mutation? No.Mutations that increase the chance of survival of an organism can become much more common in a population. A small advantage can lead to big changes in the population very quickly. How do you get a population of dark colored mice? In dark environments, the dark colored mice have an advantage they survive better and have more offspring. ![]() (Darker fur is favorable in the dark environment and harmful in the light.) Mutations are favored, rejected, or neutral depending upon an organism’s environment. How does a dark mouse appear in a population of light mice? Gene mutations cause the darker mice.The environment “selects” those individuals with the most favorable traits to survive and reproduce. What causes the overall differences in mouse fur color (big picture)? The differences in mouse fur color are caused by natural selection.The mice’s underbellies are white because there’s no selective pressure for it to be dark the predators come from above so it doesn’t matter what color the bellies are. Why do the pocket mice in the dark lava environment have dark fur on top and white underbellies? The d arker fur on the top of their bodies provides camouflage so predators won’t see them. ![]()
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