Indeed, in the last 30 years a limited progress has been made in GBM treatment with current first-line standards-of-care involving maximal safe tumor resection with adjuvant temozolomide (TMZ)-based chemotherapy and radiotherapy. Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in adult humans, characterized by a poor prognosis despite the existence of multimodal therapy. Primarily, “Reprogramming Therapy”, which is aimed at reverting the malignant phenotype, is now considered a promising strategy for GBM therapy. Therefore, the emerging roles of BET protein in glioblastoma onco-biology and the compelling demand for more effective therapeutic strategies suggest that BET family members could be promising targets for translational breakthroughs in glioblastoma treatment. Interestingly, epigenome dysregulation associated with loss of cellular identity and functions are emerging as crucial features of glioblastoma pathogenesis. Recently, new insights are emerging about the glioblastoma cellular origin, leading to the hypothesis that several putative mechanisms occur during gliomagenesis. Glioblastoma is the most aggressive form of glioma, characterized by a very poor prognosis despite the application of a multimodal therapy. Transcriptome handling ability of BET proteins suggests a key role in the modulation of cell plasticity, both in fate decision and in lineage commitment during embryonic development and in pathogenic conditions, including cancerogenesis. The survival and reproductive success of an individual is directly related to how their traits help them to function and survive in their environment.BET proteins are a family of multifunctional epigenetic readers, mainly involved in transcriptional regulation through chromatin modelling. Mutations are random, but natural selection is not random. Is evolution a random process? Evolution is not a random process.Evolution repeats itself in different environments. Different mutations can cause the same phenotype (trait). Did the mice on each of the dark lava flows have the same mutation? No.Mutations that increase the chance of survival of an organism can become much more common in a population. A small advantage can lead to big changes in the population very quickly. How do you get a population of dark colored mice? In dark environments, the dark colored mice have an advantage they survive better and have more offspring. (Darker fur is favorable in the dark environment and harmful in the light.) Mutations are favored, rejected, or neutral depending upon an organism’s environment. How does a dark mouse appear in a population of light mice? Gene mutations cause the darker mice.The environment “selects” those individuals with the most favorable traits to survive and reproduce. What causes the overall differences in mouse fur color (big picture)? The differences in mouse fur color are caused by natural selection.The mice’s underbellies are white because there’s no selective pressure for it to be dark the predators come from above so it doesn’t matter what color the bellies are. Why do the pocket mice in the dark lava environment have dark fur on top and white underbellies? The d arker fur on the top of their bodies provides camouflage so predators won’t see them.
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